One of the things I like about
slide is that anything goes.
With a Fender guitar, I use a set of DR 10's with a 12 on top, and it works fine. However, I usually go from guitar to COMPRESSOR to BSM for bright & silky tones, or from guitar to ETERNITY OVERDRIVE for heavier tones. The ideal tone solution would probably be to use heavy strings, heavy slides, heavy cords, heavy overdrives, and heavy amps

But I have to be able to play chords and single note leads as well as slide, so I go with the 10's/12 solution.
Some folks get so uptight about what they use......
"Impossible" is just someone else's opinion.... its a dare, not a fact.