you mean amp settings. I use my guitar modeler mostly so I don't bother with them much. This link should give you some ideas.
http://www.onlineguitarlessons.co.uk/settings.php
If your talking pup (pickup) settings, it's what sounds best to you. I usually play lead in neck or middle . rythm in middle or bridge and
slide in bridge position, but not knowing what your guitar sounds like, I can't say what would work for you.