I periodically try sliding in standard, and pretty soon I get frustrated and leave it alone because I really don't know how to PLAY in standard tuning. Open tunings are very intuitive to me, and modal tunings like standard aren't. It just takes massive amounts of practice and memorization.
The dissonant string problem, though, is a lot easier to cope with if you're picking with bare fingers. The unused fingers can readily mute the strings that aren't being played.
And one little trick is that strings 2-4 of standard are the same as Open G, which I am fairly familiar with. You can rest your picking thumb between the 5th and 6th strings, rest your pinky against the first string, and play the remaining strings with the other fingers to get partial Open G. It's easily possible to play all of the main riffs of "Freebird," for example, in this way so it's identical in standard or Open G.
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