Some great advice here regarding scales, chord tones and the like but I think I can simplify all that. A solo is nothing more than a way to give the singer a break and keep the song from getting monotonous at the same time. Basically all you're doing is "singing" the melody with your guitar. In short, a simple way to get started with solos, learn to play what the singer is singing, note for note. Build from there by putting your own "twists" into it. Go up an octave, down an octave, bends, vibratos, etc... Remember, the singer has to stop to take a breath now and then, so should the guitar. Took me a long time to figure that out. If I'd known it years ago it might have came easier for me.
Something to think about, anyway.
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