IF that is the same Behringer I have, you need to go into the windows mixing board/master volume menu thingy(I click on the little speaker in the lower right hand corner of the screen). Then under the options menu(not sure if vista has the same layout as XP??....I used vista one time on my Dad's computer and hated it so I never upgraded) anyway, you change the "mixer device" from your current sound card, to the interface(which is its own soundcard I think). I'm not a pro at this so maybe this info was useless, but that is how I got it to work.
Another thing I noticed is when you have it hooked up, you have to use headphones with the interface(or plug the speakers into the 1/4 output side) to hear anything unless you continuously switch back and forth with the soundcards.
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