I did encounter some pieces in F# (which contains an E#), although I can't recall any of their names. I can tell you, 6 sharps at the start of a piece of music really looks like OVERKILL
That is, if you're accustomed to standard notation anyway
Great advantage to playing in "weird" keys on the guitar is you just
slide around your patterns along the neck, or better, use a capo and you're good to go.