As far as the sound difference goes, the bridge (or humbucker pick up). gives a more trebly (if that's a word) sound, supposedly better for lead playing. The bridge pick up has a fatter sound (better for rythm playing. The others are obviously somewhere in between. I have also heard that the two single coil pick ups are out of phase and when played together have a humbucking effect. How much truth there is in that I'm sure someone will either confirm or refute.
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