Try setting it up as neutral as possible, clean channel, no effects or onboard distortion, and eq set the middle (knobs on 5, graphics on 0).
Then develop the sound your looking for thru the MFX of choice as completely as possible. Adjustments on the amp should be made last to compensate for any "tendencies" of the amp to color one frequency more than the rest.
All I usually need to do is cut the midrange a bit on any guitar amp.
All of that is to "make do" with what you have... and you should try a keyboard or other flat response amp when considering your next purchase.
Remember, wherever you go... there you are.
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