I would guess that the humbuckers probably have a boominess or higher ouput in the lower strings relative to the higher strings. So in a way you could say it's too hot on those strings or needs some EQ in front of the amp. The problem may be excentuated by the impedance matchup between the guitar and amp which could cause a resonant peak in those lower frequencies.
I guess it's simpler just to say it too hot. But considering that people intentionally buy "hot" pickups it could lead you to wrong conclusions about the amp and how well it works with hot pickups. My guess is that it doesn't tolerate "muddy" pups well. I have a stock Epi Dot that has HBs that I would characterize as a bit muddy.
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