even in a 12 bar sequence , you still have different chords - like in a blues shuffle using A , D and E you can change your pentatonic to a D pentatonic or E when the chord changes.
with blues , its sounds good if you just use the extra notes in passing , and not to stop on them .
eg - in an A 12 bar you could add F# and B notes which are used frequently but mainly in passing - it just adds a little flavour .
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